AustralieFrV1, Main, Exploration, bibRecord, 003B93

Aryl hydrocarbon receptor control of a disease tolerance defense pathway

Identifieur interne : 003B93 ( Main/Exploration ); précédent : 003B92; suivant : 003B94

Aryl hydrocarbon receptor control of a disease tolerance defense pathway

Auteurs : Alban Bessede [Italie, France] ; Marco Gargaro [Italie] ; Maria T. Pallotta [Italie] ; Davide Matino [Italie] ; Giuseppe Servillo [Italie] ; Cinzia Brunacci [Italie] ; Silvio Bicciato [Italie] ; Emilia Mc Mazza [Italie] ; Antonio Macchiarulo [Italie] ; Carmine Vacca [Italie] ; Rossana Iannitti [Italie] ; Luciana Tissi [Italie] ; Claudia Volpi [Italie] ; Maria L. Belladonna [Italie] ; Ciriana Orabona [Italie] ; Roberta Bianchi [Italie] ; Tobias Lanz [Allemagne] ; Michael Platten [Allemagne] ; Maria A Della Fazia [Italie] ; Danilo Piobbico [Italie] ; Teresa Zelante [Italie] ; Hiroshi Funakoshi [Japon] ; Toshikazu Nakamura [Japon] ; David Gilot [France] ; Michael S. Denison [États-Unis] ; Gilles J. Guillemin [Australie] ; James B. Duhadaway [États-Unis] ; George C. Prendergast [États-Unis] ; Richard Metz [États-Unis] ; Michel Geffard [France] ; Louis Boon [Pays-Bas] ; Matteo Pirro [Italie] ; Alfonso Iorio [Canada] ; Bernard Veyret [France] ; Luigina Romani [Italie] ; Ursula Grohmann [Italie] ; Francesca Fallarino [Italie] ; Paolo Puccetti [Italie]

Source :

Nature [ 0028-0836 ] ; 2014.

RBID : PMC:4098076

Descripteurs français

English descriptors

KwdEn :
- Animals, Bacterial Infections (immunology), Bacterial Infections (metabolism), Disease Resistance (drug effects), Disease Resistance (genetics), Disease Resistance (immunology), Endotoxemia (genetics), Endotoxemia (immunology), Endotoxemia (metabolism), Enzyme Activation (drug effects), Gene Expression Regulation (drug effects), Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism), Inflammation (enzymology), Inflammation (genetics), Inflammation (metabolism), Kynurenine (metabolism), Lipopolysaccharides (pharmacology), Mice, Phosphorylation, Receptors, Aryl Hydrocarbon (genetics), Receptors, Aryl Hydrocarbon (metabolism), Signal Transduction, Tryptophan Oxygenase (metabolism), src-Family Kinases (metabolism).
MESH :
- chemical , genetics : Receptors, Aryl Hydrocarbon.
- chemical , metabolism : Indoleamine-Pyrrole 2,3,-Dioxygenase, Kynurenine, Receptors, Aryl Hydrocarbon, Tryptophan Oxygenase, src-Family Kinases.
- drug effects : Disease Resistance, Enzyme Activation, Gene Expression Regulation.
- enzymology : Inflammation.
- genetics : Disease Resistance, Endotoxemia, Inflammation.
- immunology : Bacterial Infections, Disease Resistance, Endotoxemia.
- metabolism : Bacterial Infections, Endotoxemia, Inflammation.
- chemical , pharmacology : Lipopolysaccharides.
- Animals, Mice, Phosphorylation, Signal Transduction.

Abstract

Summary

Disease tolerance is the ability of the host to reduce the impact of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (“endotoxin tolerance”). We found that a first exposure to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase 2, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR complex-associated Src kinase activity promoted IDO1 phosphorylation and signaling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in gram-negative and gram-positive infections, pointing to a role for AhR in contributing to host fitness.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098076

DOI: 10.1038/nature13323
PubMed: 24930766
PubMed Central: 4098076

Affiliations:

Allemagne, Australie, Canada, France, Italie, Japon, Pays-Bas, États-Unis
Bade-Wurtemberg, Californie, District de Karlsruhe, Iowa, Ontario, Pennsylvanie, Région Bretagne, Utrecht (province)
Hamilton (Ontario), Heidelberg, Rennes, Utrecht
Université McMaster

Le document en format XML

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<author><name sortKey="Orabona, Ciriana" sort="Orabona, Ciriana" uniqKey="Orabona C" first="Ciriana" last="Orabona">Ciriana Orabona</name>
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<author><name sortKey="Piobbico, Danilo" sort="Piobbico, Danilo" uniqKey="Piobbico D" first="Danilo" last="Piobbico">Danilo Piobbico</name>
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<author><name sortKey="Zelante, Teresa" sort="Zelante, Teresa" uniqKey="Zelante T" first="Teresa" last="Zelante">Teresa Zelante</name>
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<author><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name>
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<author><name sortKey="Nakamura, Toshikazu" sort="Nakamura, Toshikazu" uniqKey="Nakamura T" first="Toshikazu" last="Nakamura">Toshikazu Nakamura</name>
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<author><name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name>
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<author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name>
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</placeName>
<wicri:cityArea>Department of Environmental Toxicology, University of California, Davis</wicri:cityArea>
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<author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name>
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<author><name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name>
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<author><name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name>
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<author><name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name>
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<author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
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<author><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name>
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<author><name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name>
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<author><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name>
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<placeName><settlement type="city">Hamilton (Ontario)</settlement>
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<author><name sortKey="Veyret, Bernard" sort="Veyret, Bernard" uniqKey="Veyret B" first="Bernard" last="Veyret">Bernard Veyret</name>
<affiliation wicri:level="1"><nlm:aff id="A2">University of Bordeaux, IMS Laboratory, Pessac, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author><name sortKey="Romani, Luigina" sort="Romani, Luigina" uniqKey="Romani L" first="Luigina" last="Romani">Luigina Romani</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Grohmann, Ursula" sort="Grohmann, Ursula" uniqKey="Grohmann U" first="Ursula" last="Grohmann">Ursula Grohmann</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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<author><name sortKey="Iannitti, Rossana" sort="Iannitti, Rossana" uniqKey="Iannitti R" first="Rossana" last="Iannitti">Rossana Iannitti</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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<author><name sortKey="Tissi, Luciana" sort="Tissi, Luciana" uniqKey="Tissi L" first="Luciana" last="Tissi">Luciana Tissi</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Volpi, Claudia" sort="Volpi, Claudia" uniqKey="Volpi C" first="Claudia" last="Volpi">Claudia Volpi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Belladonna, Maria L" sort="Belladonna, Maria L" uniqKey="Belladonna M" first="Maria L" last="Belladonna">Maria L. Belladonna</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Orabona, Ciriana" sort="Orabona, Ciriana" uniqKey="Orabona C" first="Ciriana" last="Orabona">Ciriana Orabona</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Bianchi, Roberta" sort="Bianchi, Roberta" uniqKey="Bianchi R" first="Roberta" last="Bianchi">Roberta Bianchi</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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<author><name sortKey="Lanz, Tobias" sort="Lanz, Tobias" uniqKey="Lanz T" first="Tobias" last="Lanz">Tobias Lanz</name>
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<affiliation wicri:level="3"><nlm:aff id="A7">Department of Neurooncology, University Hospital, Heidelberg, Germany</nlm:aff>
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<author><name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name>
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<affiliation wicri:level="3"><nlm:aff id="A7">Department of Neurooncology, University Hospital, Heidelberg, Germany</nlm:aff>
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<author><name sortKey="Fazia, Maria A Della" sort="Fazia, Maria A Della" uniqKey="Fazia M" first="Maria A Della" last="Fazia">Maria A Della Fazia</name>
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<author><name sortKey="Piobbico, Danilo" sort="Piobbico, Danilo" uniqKey="Piobbico D" first="Danilo" last="Piobbico">Danilo Piobbico</name>
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<wicri:regionArea>Department of Clinical and Experimental Medicine, University of Perugia</wicri:regionArea>
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<author><name sortKey="Zelante, Teresa" sort="Zelante, Teresa" uniqKey="Zelante T" first="Teresa" last="Zelante">Teresa Zelante</name>
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<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name>
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<wicri:regionArea>Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa</wicri:regionArea>
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<author><name sortKey="Nakamura, Toshikazu" sort="Nakamura, Toshikazu" uniqKey="Nakamura T" first="Toshikazu" last="Nakamura">Toshikazu Nakamura</name>
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<author><name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name>
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<author><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name>
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</placeName>
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<author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name>
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<wicri:regionArea>Australian School of Advanced Medicine (ASAM), Macquarie University, NSW, 2109</wicri:regionArea>
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<author><name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name>
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<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Lankenau Institute for Medical Research, Wynnewood</wicri:cityArea>
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</author>
<author><name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
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<author><name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name>
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<placeName><region type="state">Iowa</region>
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<author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
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<wicri:regionArea>University of Bordeaux, IMS Laboratory, Pessac</wicri:regionArea>
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<author><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name>
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<author><name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name>
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<wicri:regionArea>Department of Clinical and Experimental Medicine, University of Perugia</wicri:regionArea>
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</author>
<author><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name>
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<wicri:regionArea>University of Bordeaux, IMS Laboratory, Pessac</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Experimental Medicine, University of Perugia, Perugia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, University of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature</title>
<idno type="ISSN">0028-0836</idno>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bacterial Infections (immunology)</term>
<term>Bacterial Infections (metabolism)</term>
<term>Disease Resistance (drug effects)</term>
<term>Disease Resistance (genetics)</term>
<term>Disease Resistance (immunology)</term>
<term>Endotoxemia (genetics)</term>
<term>Endotoxemia (immunology)</term>
<term>Endotoxemia (metabolism)</term>
<term>Enzyme Activation (drug effects)</term>
<term>Gene Expression Regulation (drug effects)</term>
<term>Indoleamine-Pyrrole 2,3,-Dioxygenase (metabolism)</term>
<term>Inflammation (enzymology)</term>
<term>Inflammation (genetics)</term>
<term>Inflammation (metabolism)</term>
<term>Kynurenine (metabolism)</term>
<term>Lipopolysaccharides (pharmacology)</term>
<term>Mice</term>
<term>Phosphorylation</term>
<term>Receptors, Aryl Hydrocarbon (genetics)</term>
<term>Receptors, Aryl Hydrocarbon (metabolism)</term>
<term>Signal Transduction</term>
<term>Tryptophan Oxygenase (metabolism)</term>
<term>src-Family Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Activation enzymatique ()</term>
<term>Animaux</term>
<term>Cynurénine (métabolisme)</term>
<term>Endotoxémie (génétique)</term>
<term>Endotoxémie (immunologie)</term>
<term>Endotoxémie (métabolisme)</term>
<term>Indoleamine-pyrrole 2,3,-dioxygenase (métabolisme)</term>
<term>Infections bactériennes (immunologie)</term>
<term>Infections bactériennes (métabolisme)</term>
<term>Inflammation (enzymologie)</term>
<term>Inflammation (génétique)</term>
<term>Inflammation (métabolisme)</term>
<term>Lipopolysaccharides (pharmacologie)</term>
<term>Phosphorylation</term>
<term>Récepteurs à hydrocarbure aromatique (génétique)</term>
<term>Récepteurs à hydrocarbure aromatique (métabolisme)</term>
<term>Régulation de l'expression des gènes ()</term>
<term>Résistance à la maladie ()</term>
<term>Résistance à la maladie (génétique)</term>
<term>Résistance à la maladie (immunologie)</term>
<term>Souris</term>
<term>Transduction du signal</term>
<term>Tryptophane 2,3-dioxygenase (métabolisme)</term>
<term>src-Family kinases (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Aryl Hydrocarbon</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Indoleamine-Pyrrole 2,3,-Dioxygenase</term>
<term>Kynurenine</term>
<term>Receptors, Aryl Hydrocarbon</term>
<term>Tryptophan Oxygenase</term>
<term>src-Family Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Disease Resistance</term>
<term>Enzyme Activation</term>
<term>Gene Expression Regulation</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Disease Resistance</term>
<term>Endotoxemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Endotoxémie</term>
<term>Inflammation</term>
<term>Récepteurs à hydrocarbure aromatique</term>
<term>Résistance à la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Endotoxémie</term>
<term>Infections bactériennes</term>
<term>Résistance à la maladie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Bacterial Infections</term>
<term>Disease Resistance</term>
<term>Endotoxemia</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacterial Infections</term>
<term>Endotoxemia</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cynurénine</term>
<term>Endotoxémie</term>
<term>Indoleamine-pyrrole 2,3,-dioxygenase</term>
<term>Infections bactériennes</term>
<term>Inflammation</term>
<term>Récepteurs à hydrocarbure aromatique</term>
<term>Tryptophane 2,3-dioxygenase</term>
<term>src-Family kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Lipopolysaccharides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipopolysaccharides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mice</term>
<term>Phosphorylation</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
<term>Animaux</term>
<term>Phosphorylation</term>
<term>Régulation de l'expression des gènes</term>
<term>Résistance à la maladie</term>
<term>Souris</term>
<term>Transduction du signal</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Summary</title>
<p id="P2">Disease tolerance is the ability of the host to reduce the impact of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (“endotoxin tolerance”). We found that a first exposure to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase 2, which provided an activating ligand to the former, to downregulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR complex-associated Src kinase activity promoted IDO1 phosphorylation and signaling ability. The resulting endotoxin-tolerant state was found to protect mice against immunopathology in gram-negative and gram-positive infections, pointing to a role for AhR in contributing to host fitness.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Italie</li>
<li>Japon</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>District de Karlsruhe</li>
<li>Iowa</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Région Bretagne</li>
<li>Utrecht (province)</li>
</region>
<settlement><li>Hamilton (Ontario)</li>
<li>Heidelberg</li>
<li>Rennes</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université McMaster</li>
</orgName>
</list>
<tree><country name="Italie"><noRegion><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name>
</noRegion>
<name sortKey="Belladonna, Maria L" sort="Belladonna, Maria L" uniqKey="Belladonna M" first="Maria L" last="Belladonna">Maria L. Belladonna</name>
<name sortKey="Bianchi, Roberta" sort="Bianchi, Roberta" uniqKey="Bianchi R" first="Roberta" last="Bianchi">Roberta Bianchi</name>
<name sortKey="Bicciato, Silvio" sort="Bicciato, Silvio" uniqKey="Bicciato S" first="Silvio" last="Bicciato">Silvio Bicciato</name>
<name sortKey="Brunacci, Cinzia" sort="Brunacci, Cinzia" uniqKey="Brunacci C" first="Cinzia" last="Brunacci">Cinzia Brunacci</name>
<name sortKey="Fallarino, Francesca" sort="Fallarino, Francesca" uniqKey="Fallarino F" first="Francesca" last="Fallarino">Francesca Fallarino</name>
<name sortKey="Fazia, Maria A Della" sort="Fazia, Maria A Della" uniqKey="Fazia M" first="Maria A Della" last="Fazia">Maria A Della Fazia</name>
<name sortKey="Gargaro, Marco" sort="Gargaro, Marco" uniqKey="Gargaro M" first="Marco" last="Gargaro">Marco Gargaro</name>
<name sortKey="Grohmann, Ursula" sort="Grohmann, Ursula" uniqKey="Grohmann U" first="Ursula" last="Grohmann">Ursula Grohmann</name>
<name sortKey="Iannitti, Rossana" sort="Iannitti, Rossana" uniqKey="Iannitti R" first="Rossana" last="Iannitti">Rossana Iannitti</name>
<name sortKey="Macchiarulo, Antonio" sort="Macchiarulo, Antonio" uniqKey="Macchiarulo A" first="Antonio" last="Macchiarulo">Antonio Macchiarulo</name>
<name sortKey="Matino, Davide" sort="Matino, Davide" uniqKey="Matino D" first="Davide" last="Matino">Davide Matino</name>
<name sortKey="Mazza, Emilia Mc" sort="Mazza, Emilia Mc" uniqKey="Mazza E" first="Emilia Mc" last="Mazza">Emilia Mc Mazza</name>
<name sortKey="Orabona, Ciriana" sort="Orabona, Ciriana" uniqKey="Orabona C" first="Ciriana" last="Orabona">Ciriana Orabona</name>
<name sortKey="Pallotta, Maria T" sort="Pallotta, Maria T" uniqKey="Pallotta M" first="Maria T" last="Pallotta">Maria T. Pallotta</name>
<name sortKey="Piobbico, Danilo" sort="Piobbico, Danilo" uniqKey="Piobbico D" first="Danilo" last="Piobbico">Danilo Piobbico</name>
<name sortKey="Pirro, Matteo" sort="Pirro, Matteo" uniqKey="Pirro M" first="Matteo" last="Pirro">Matteo Pirro</name>
<name sortKey="Puccetti, Paolo" sort="Puccetti, Paolo" uniqKey="Puccetti P" first="Paolo" last="Puccetti">Paolo Puccetti</name>
<name sortKey="Romani, Luigina" sort="Romani, Luigina" uniqKey="Romani L" first="Luigina" last="Romani">Luigina Romani</name>
<name sortKey="Servillo, Giuseppe" sort="Servillo, Giuseppe" uniqKey="Servillo G" first="Giuseppe" last="Servillo">Giuseppe Servillo</name>
<name sortKey="Tissi, Luciana" sort="Tissi, Luciana" uniqKey="Tissi L" first="Luciana" last="Tissi">Luciana Tissi</name>
<name sortKey="Vacca, Carmine" sort="Vacca, Carmine" uniqKey="Vacca C" first="Carmine" last="Vacca">Carmine Vacca</name>
<name sortKey="Volpi, Claudia" sort="Volpi, Claudia" uniqKey="Volpi C" first="Claudia" last="Volpi">Claudia Volpi</name>
<name sortKey="Zelante, Teresa" sort="Zelante, Teresa" uniqKey="Zelante T" first="Teresa" last="Zelante">Teresa Zelante</name>
</country>
<country name="France"><noRegion><name sortKey="Bessede, Alban" sort="Bessede, Alban" uniqKey="Bessede A" first="Alban" last="Bessede">Alban Bessede</name>
</noRegion>
<name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name>
<name sortKey="Gilot, David" sort="Gilot, David" uniqKey="Gilot D" first="David" last="Gilot">David Gilot</name>
<name sortKey="Veyret, Bernard" sort="Veyret, Bernard" uniqKey="Veyret B" first="Bernard" last="Veyret">Bernard Veyret</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Lanz, Tobias" sort="Lanz, Tobias" uniqKey="Lanz T" first="Tobias" last="Lanz">Tobias Lanz</name>
</region>
<name sortKey="Lanz, Tobias" sort="Lanz, Tobias" uniqKey="Lanz T" first="Tobias" last="Lanz">Tobias Lanz</name>
<name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name>
<name sortKey="Platten, Michael" sort="Platten, Michael" uniqKey="Platten M" first="Michael" last="Platten">Michael Platten</name>
</country>
<country name="Japon"><noRegion><name sortKey="Funakoshi, Hiroshi" sort="Funakoshi, Hiroshi" uniqKey="Funakoshi H" first="Hiroshi" last="Funakoshi">Hiroshi Funakoshi</name>
</noRegion>
<name sortKey="Nakamura, Toshikazu" sort="Nakamura, Toshikazu" uniqKey="Nakamura T" first="Toshikazu" last="Nakamura">Toshikazu Nakamura</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Denison, Michael S" sort="Denison, Michael S" uniqKey="Denison M" first="Michael S" last="Denison">Michael S. Denison</name>
</region>
<name sortKey="Duhadaway, James B" sort="Duhadaway, James B" uniqKey="Duhadaway J" first="James B" last="Duhadaway">James B. Duhadaway</name>
<name sortKey="Metz, Richard" sort="Metz, Richard" uniqKey="Metz R" first="Richard" last="Metz">Richard Metz</name>
<name sortKey="Prendergast, George C" sort="Prendergast, George C" uniqKey="Prendergast G" first="George C" last="Prendergast">George C. Prendergast</name>
</country>
<country name="Australie"><noRegion><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J" last="Guillemin">Gilles J. Guillemin</name>
</noRegion>
</country>
<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Boon, Louis" sort="Boon, Louis" uniqKey="Boon L" first="Louis" last="Boon">Louis Boon</name>
</region>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Iorio, Alfonso" sort="Iorio, Alfonso" uniqKey="Iorio A" first="Alfonso" last="Iorio">Alfonso Iorio</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Aryl hydrocarbon receptor control of a disease tolerance defense pathway

Aryl hydrocarbon receptor control of a disease tolerance defense pathway

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